Present study is to analyze effect of tomato's lycopene, synthetic lycopene, its placebo form in patients of OS. Oral Lycopene therapy seemsto have a role in the management of idiopathicmale infertility. Are the health attributes of lycopene related to its antioxidant function? The aim of the present literature review was to investigate the most common antioxidants used for the treatment of male infertility and explore the doses that are associated with potential benefit on basic semen parameter results, advanced sperm function tests, Background and objectives: This study aimed to investigate the effects of tomato juice consumption on seminal plasma lycopene levels and sperm parameters in infertile men. C. Infertility. Folic acid intake was associated with an elevation in reduced:oxidised glutathione ratio . Pregnancy rates, while higher for the surgical group, was not statistically different in both groups. Lycopene administered as a pure compound has been studied in clinical trials at dosages of 8 to 75 mg/day.66, 80, 81, 82, 83, 84 Lycopene is primarily available in capsule and softgel form, with dosage guidelines from manufacturers ranging from 10 to 30 mg taken twice daily with meals. It is available in different dosage forms such as tablets, capsules, syrups and granulated powders with multivitamin combination. Free full text Asian J Androl . However, clinical benefits should not be achieved at high dose, since the evidence of calcium chelator activity of l ‐carnitine that may determine cell damage and decrease in serum calcium. The antioxidant properties help balance free radical activity in the body and in doing so, may offer protection against certain diseases, keep bones strong and healthy, and help eyesight by helping delay or prevent cataracts, macular degeneration, and other age-rela… Therapeutic dosage of lycopene range from 6-60 mg daily. Oral Lycopene therapy seemsto have a role in the management of idiopathicmale infertility. A 2013 study in the journal Fertility and Sterility showed men who consumed a diet rich in lycopene had better quality sperm, particularly morphology. Protective role of lycopene on polychlorinated biphenyls (Aroclor 1254)-induced adult rat Sertoli cell dysfunction by increased oxidative stress and endocrine disruption, Comparative analysis of lycopene in oxidative stress, Male infertility: A critical review of pharmacologic management, Sperm Diagnostics and Selecting Healthier Spermatozoa, Ejaculatory duct obstruction in the infertile male: Experience of 7 cases at Ramathibodi Hospital. Normal testicles and secondary sex characteristics were noted in all. Once again, lycopene comes to the rescue. Transrectal ultrasonography (TRUS) and/or vasography can be done to confirm the dilatation of seminal vesicles and obstruction of the ejaculatory duct. All antioxidants have shown a role in destroying free radicals and thereby reducing the damage to all cells in the body. But how does that work? Symptoms of menopause. In fact, it’s lycopene that gives vegetables like tomatoes their red color. Gac fruit contains 70 times as much lycopene as tomatoes, which are one of the primary sources of lycopene in the American diet. … This discovery could drastically renew couples’ outlook on their ability to conceive who have been struggling due to male factor infertility. While sunburns aren’t exclusive to men, men are statistically more likely to develop melanoma. Melanoma is caused by extensive or prolonged UV exposure, often from poor protection against sunburns! The top sources for lycopene include: Whichever food source you choose, getting a healthy dose of lycopene is the first step in taking care of your health! 13:37 ↩ Chen J, Song Y, Zhang L. Lycopene/tomato consumption and the risk of prostate cancer: a systematic review and meta-analysis of prospective studies. Differently processed tomato products are also rich sources of lycopene. The good news is that there’s a way to combat these issues! A variety of epidemiological trials have suggested that higher intake of lycopene-containing foods (primarily tomato products) or blood lycopene concentrations are associated with decreased cardiovascular disease and prostate cancer risk. Lycopene, as an antioxidant, reduces oxidative stress. Durairajanayagam D, Agarwal A, Ong C, Prashast P. Lycopene and male infertility. Oxidation of cholesterol is a process that can cause a great deal of cell damage. Asian Journal of Andrology (2014) 16, 420–425; doi: 10.4103/1008-682X.126384; published online: 18 March 2014 Early research shows that taking lycopene by mouth daily for 3 months improves sperm quality in some men with fertility problems due to unknown causes. , which are one of the primary sources of lycopene in the American diet. Your body converts some carotenoids to retinol, a form of vitamin A. Lycopene has no vitamin A activity, but getting the recommended daily dose of this nutrient can provide antioxidant benefits that may help keep you healthy and feeling young. Early research shows that taking lycopene by mouth daily for 3 months improves sperm quality in some men with fertility problems due to unknown causes. Increasing evidence suggests that environmental pollutants including polychlorinated biphenyls (PCBs) are male infertility, which is associated with oxidative stress. Areas covered: Lycopene and male infertility Damayanthi Durairajanayagam1,2, Ashok Agarwal 1, Chloe Ong , Pallavi Prashast Excessive amounts of reactive oxygen species (ROS) cause a state of oxidative stress, which result in sperm membrane lipid peroxidation, DNA damage and apoptosis, leading to decreased sperm viability and motility. Human trials have reported sperm parameter improvement and pregnancy rates with supplementation of 4–8 mg of lycopene daily for 3–12 months. By age 80, men are 3 times as likely as women are to develop melanoma. Conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility). L- Carnitine plays important role in the formation of sperm. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility. Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): https://doi.org/10.4103/1008-6... (external link) “Oxidative stress may play a role in male infertility pathogenesis and while reactive oxygen species play a role in normal sperm function, disequilibrium of reactive oxygen species and antioxidant defence appears to be detrimental. The body obtains antioxidants from many of the foods that comprise a healthy diet however many people fail to eat enough of these recommended foods. Male infertility represents a very challenging area of clinical medicine. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. 3. In general, the human trials analyzed in this review showed that 4–8 mg of daily lycopene supplementation for 3–12 months is sufficient to treat male infertility.9,29 This translates to the intake of approximately 150 g of raw tomatoes or 80 g of watermelon daily.15 However, more research and clinical trials have to be conducted on humans to determine the most accurate therapeutic dosage. Conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility). We conclude that there is an overall shortage of supportive evidence for the “antioxidant hypothesis” as lycopene’s major in vivo mechanism of action. What is Lycopene. Lycopene was found to boost sperm count by as much as 70%. Consuming lycopene is quickly becoming a new way for couples wanting to start a family to get a second chance! In our review of human and animal trials with lycopene, or lycopene-containing extracts, there is limited support for the in vivo antioxidant function for lycopene. This means they aren't able to conceive a child, even though they've had frequent, unprotected sexual intercourse for a year or longer. Lycopene is a phytochemical, found in tomatoes having singlet oxygen quenching ability higher than other antioxidants, participates in most of chemical reactions to protect critical cellular biomolecules. Study includes 45 patients having oxidative stress, age 40-60 years and 30 age and sex matched healthy control. 4. For couples struggling with infertility, this is a huge discovery; almost 50% of infertility cases are caused by male sperm health issues. Continued improvements appeared to be evident for up to at least 6 months of administration." Maximum improvement seems tooccur in the sperm concentration (66% cases).Patients without severe oligospermia (spermdensity >5 million/ml) may be given a trialof therapy with lycopene. Each can of gac has a whopping 16mg of lycopene. Excessive generation of reactive oxygen species (ROS) containing free oxygen radicals has been iden-tified as one of the causes of male infertility. “ A 2000 study in India examined 30 men with idiopathic infertility. Lycopene is one of the most vital secret ingredients that makes Gac the magical solution for handling a wide variety of health issues. Multiple over‐the‐counter (OTC) therapies have been historically used for male fertility, including herbs, vitamins, and nutritional supplements (Crimmel et al, 2001).Because infertility affects 15% of couples trying to conceive, with male factor implicated solely or in combination with a female factor in 50% of the cases, many male patients use these therapies (Sharlip et al, 2002). We’ve mentioned there are multiple health benefits of consuming fruits like Gac that contain lycopene, particularly for men. Lycopene helps combat these free radicals and keeps their levels balanced in your body. Sertoli cell functional proteins such as connexin 43, transferrin and androgen-binding protein expressions and the level of lactate were significantly decreased. 4. The age ranged from 32-45 years old (mean 34.5). medical treatment. However, in a report published in International Urology and Nephrology Journal in which men with impaired fertility were given 2 mg of lycopene twice a day, 66 percent saw improved sperm concentration and 53 percent had improved mobility. Transurethral resection of ejaculatory duct (TURED) was done in 6 cases and transurethral incision of ejaculatory duct (TUIED) was done in 1 case. In this randomized, double-blind, placebo-controlled trial study, 44 infertile men with oligozoospermia were randomly divided into two groups: The experimental group was supplemented with 25 mg of lycopene, … 2014 May-Jun; 16(3): 420–425. Raj MV, Selvakumar K, Krishnamoorthy G, Revathy S, Elumalai P, et al. This leads to conditions such as cancer, heart disease, macular degeneration, diabetes, joint deterioration and accelerated aging. The protective role of lycopene against various toxicants on various organs and its association with decreased oxidative stress seems to be well established. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene for male infertility treatment . However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility. Male infertility affects up to half of couples who cannot conceive. However, the most common therapeutic scheme suggested consists of an oral dosage of 150 UI a day for at least three months [25]. Menopausal symptoms . Menopausal symptoms. Check out our. However, most studies done in this regard are observational . So far, a clinical study, involving 47,365 persons, has demonstrated the reduced risk of prostate cancer following lycopene intake, and a reduction of male infertility and improvement of sperm quality using lycopene as a dietary supplement, thus increasing sperm number and viability [33,37]. Hence, there is not agreement about the dosage. Lycopene (molecular formula: C40H56) is a linear, unsaturated hydrocarbon carotenoid, the major bright red pigment, a phytochemical found in fruits such as tomatoes and other red fruits such as papaya, pink grapefruit, apricots, red oranges, watermelon, rosehips and guavas 3).Lycopene is the most common carotenoid in the human body and is one of the most potent … With all these amazing properties of lycopene, you’re probably wondering where exactly gac fruit fits into this picture. The optimal dose of lycopene is not known. May Treat Infertility. HCG: 500 to 1000 units IM 3 times a week for 3 weeks, then 500 to 1000 units IM 2 times a week for 3 weeks OR 4000 units IM 3 times a week for 6 to 9 months, then 2000 units IM 3 times a week for 3 months Uses:-Selected cases of hypogonadotropic hypogonadism in males [Intra-uterine inseminations with hyperstimulation in male infertility], Renal and Gonadal Venography in Male Infertility. For Positive Outcome in Treatment of Male Infertility. In addition, the city environments are overloaded with extra free radicals courtesy of sources like industrial pollution, motor vehicles and smoking. Treatment for male infertility A 2000 study in India examined 30 men with idiopathic infertility. Lycopene is a type of carotenoid, or plant-based pigment, that gives tomatoes, pink grapefruit and watermelon their red color. From the book Milestones in Medicine: L-carnitine & acetylcarnitine in male infertility: "These positive effects of both L-carnitine and acetylcarnitine on sperm quality were observed after at least 2 months of use, consistent with the 74-day sperm maturation cycle. Lycopene therapy in idiopathic male infertility – a preliminary report Narmada P. Gupta & Rajeev Kumar Department of Urology, All India Institute of Medical Sciences, Ansari Nagar, 110029,New Delhi, India Abstract. In today’s world, it’s tougher than ever to stay healthy, fight disease, and keep our bodies in tip-top shape. For couples struggling with infertility, this is a huge discovery; almost 50% of infertility cases are caused by male sperm health issues. Conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility). However, spermatozoa chilled in lycopene-enriched extenders showed significantly lower malonaldehyde levels than those chilled without lycopene, while the addition of lycopene to the freezing medium served to maintain the lipid peroxidation levels observed in fresh semen. Elevated levels of ROS are a major In fact, it’s lycopene that gives vegetables like tomatoes their red color. The medical treatment showed to be effective in elective cases. Well, the answer is simple. The man in the Harvard study with the greatest protection against cancer consumed at least 6.5 mg per day. The beneficial effects of lycopene observed could be related to its capacity to diminish sperm lipid peroxidation during refrigeration or cryopreservation. Background and objectives: This study aimed to investigate the effects of tomato juice consumption on seminal plasma lycopene levels and sperm parameters in infertile men. Average daily intake levels of lycopene range from 0.70 to 25.20 mg/day. Our laboratory has postulated that metabolic products of lycopene, the lycopenoids, may be responsible for some of lycopene’s reported bioactivity. Nevertheless, the surgical treatment remains the better choice in the treatment of subfertility associated to varicocele. Maximum improvement seems to occur in the sperm concentration (66% cases). Lycopene is a carotenoid found in foods such as tomatoes, tomato products, watermelon, pink grapefruit and guava. Vasography was used as the diagnosis tool in all of the cases and 71 per cent of seminal vesicles were >1.5 cm in diameter and all the rest were 1 cm in diameter. Additionally, its quality of reducing harmful “free radical” compounds also makes it a great way to combat heart disease. The success rate is not associated with the number of sperm abnormalities in our study. That makes this antioxidant a fantastic, healthy way of reducing cancer risk and staying healthy! Each teaspoon of gac powder contains 8.8mg of lycopene, which makes it another great way of incorporating this antioxidant into your diet. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. Methods and study design: Subjects were male infertility patients with poor sperm concentration (<20×10 6/mL) and/or motility (<50%). considerably in the dosage or combinations used, as well as outcome measures. Of all infertility cases, approximately 40-50% are due to "male factor" infertility, according to NBCI. And, it limits tumor growth in the prostate. Contraception, Fertilité, Sexualité (1992). However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility. Up to 15 percent of couples are infertile. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility. Ejaculatory duct obstruction is a treatable cause of male infertility. Lycopene is found in tomatoes, watermelons, red oranges, pink grapefruits, apricots, rosehips, and guavas. A new discovery could transform the way male infertility is treated in the future. The leading cause of male infertility stems from a loss of spermatozoa function, ultimately resulting in a loss of fertilization potential . Reprod Sci 2014; 21: 89-101. Antioxidants such as carotenoids function against free radical damages. It is found in high concentrations in the testes and seminal plasma and decreased levels have been demonstrated in men suffering from infertility. … According to MayoClinic.com, recommended doses of lycopene generally range from 2 to 30 mg per day for up to six months. Except for one variable all the others failed to show a significant difference by statistical analysis between both treatments, however, the surgical treatment resulted in higher values when compared to the medical one. In young men, taking the recommended dose of lycopene increased sperm mobility and healthy shaped sperm by 40%. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. Reproductive Biology and Endocrinology. There is a huge need to advance and develop andrologic diagnostic techniques, focusing on the metabolomics and proteomics of the sperm, seminal plasma, and testicular tissue. Numerous epidemiological studies have linked diets that are high in lycopene intake with a reduced risk of cancer and degenerative diseases. Hence, there is a need to increase the dietary intake of an effective antioxidant such as lycopene. That’s where lycopene comes in again. Lycopene inhibits free radical damage to LDL cholesterol with its antioxidant action preventing oxidation to LDL cholesterol. Thus, the aim of this study was to evaluate the effect of lycopene supplementation on spermatogram and seminal oxidative stress. Varicocele is one of the main causes of infertility in men. Lycopene provides health benefits by being absorbed into body tissues and mounting a defense against damaging free radicals that if left unchecked, create oxidative damage to cells. That means that by consuming gac fruit, you can get well up to the recommended daily dose of 16mg of lycopene per day. Lycopene is a carotenoid and antioxidant that is found in several different kinds of vegetables. “The antioxidant properties of lycopene have been the focus of lycopene’s action on male infertility to date,” the team say. There is a lack of studies investigating the effects of SOD oral supplementation on human sperm. 5. The men would have needed to eat 2kg of cooked tomatoes each day to get the equivalent dose of lycopene. We evaluated the effect of oral lycopene therapy in The findings point out that lycopene protects the Sertoli cell function by preventing PCBs-induced oxidative stress and endocrine disruption. Oxidative stress and consequently apoptosis activation contribute to varicocele pathogenesis, worsening its prognosis. Oxidative stress biomarkers MDA, SOD, GPX, GR, GSH, Catalase, vitamin C and E were measured. Many products that we purchase and consume are full of harmful chemicals that can wreak lasting havoc on our minds and bodies. At GacLife, we want you to be the healthiest version of yourself. Its antioxidant effect includes a considerable reactive oxygen species scavenging activity, which allows lycopene to prevent lipid per oxidation and DNA damage. It may play a significant role in many health concerns, including cardiovascular disease, diabetes, cancer, osteoporosis, liver disease, cataracts, and male infertility. Dietary intake of tomato lycopene is beneficial to fight against OS but in the synthetic form it is more bioavailable and more effective against OS. Let’s break it down. Which brand of lycopene is best? No matter how you choose to incorporate lycopene into your diet, GacLife is here to support you in that! Infertility affects up to 15% of the population globally , and furthermore, male infertility is responsible in about 20% of cases but may contribute to 40% of infertile couples . In the long-term follow-up, 4 of 7 (57%) were able to impregnate their wives. It has been suggested that oxidative damage may negatively affect sperm. Adult male rats were divided into four (vehicle control, lycopene, PCBs and PCBs+lycopene treated) groups. (See What It Does). lycopene against male infertility, it is imperative to know the details about lycopene. 5. After the experimental period (30days), the animals were decapitated for the blood collection and testes were removed for the isolation of Sertoli cells. In an infertile male with oligospermia or azoospermia with low ejaculate volume, normal secondary sex characteristics, testes and normal hormonal profiles, ejaculatory duct obstruction is suggested. Catalase The administration of these molecules in the treatment of male infertility (alone or in combination) is, therefore, a rational and effective therapeutic strategy. A new study of a small cohort of men has found that the pigment which gives the fruit its red colour, known as lycopene, could boost sperm quality, specifically around size and swimming capabilities. Six months after operation 6 of 7 (86%) showed improvement of semen analysis. A new study of a small cohort of men has found that the pigment which gives the fruit its red colour, known as lycopene, could boost sperm quality, specifically around size and swimming capabilities. Improving vision and preventing cataract development, Contributing to bone growth and strengthening, No matter how you choose to incorporate lycopene into your diet, GacLife is here to support you in that! Greater lipid peroxidation was detected in refrigerated compared to fresh or cryopreserved spermatozoa. In a recent study on the effects of lycopene on sperm count and quality, researchers found that consuming 14mg of lycopene per day can actually greatly benefit sperm production! . Maximum improvement seems tooccur in the sperm concentration (66% cases).Patients without severe oligospermia (spermdensity >5 million/ml) may be given a trialof therapy with lycopene. Infertility is a major, worldwide problem that is affected, and mediated, by several factors, in particular, oxidative stress. All of the patients had azoospermia without other symptoms related to ejaculatory duct obstruction such as painful ejaculation, perineal or testicular pain. The recommended dose of lycopene is 16mg per day, but it can be tough to get that much lycopene in your diet. Male factors, including decreased semen quality, are responsible for ~25% of cases of infertility (Evers, 2002; Sharlip et al., 2002) and, in the USA, the prevalence of men seeking help for fertility is estimated at 3.3–4.7 million (Anderson et al., 2009). Fertility experts said more studies were needed involving men known to have fertility problems. It is one of a number of pigments called carotenoids. Usual Adult Dose for Hypogonadism - Male. Expert opinion: Hence, the present study was designed to find out whether PCBs disrupt Sertoli cell function by inducing oxidative stress or endocrine disruption? In particular, men’s health issues are becoming more and more prevalent. In over a third of these couples, male infertility plays a role.Male infertility is due to low sperm production, abnormal sperm function or blockages that prevent the delivery of sperm. J Nutr 1997;127:1833-7. Evidence-based medical therapy for male infertility is an attractive research area where a large number of clinical trials, controlled and uncontrolled, using different types of medications have been conducted yielding variable results and outcomes. Blood samples were collected at the enrollment, end of 2 weeks of lycopene restricted diet and after 10 weeks of lycopene supplementation. catheter over a competent valve. 1 mg/ml of lycopene were stored at 5°C for 48 h or cryopreserved as pellets and the following variables determined in fresh samples and samples stored chilled or frozen: sperm motility, viability, osmotic resistance, DNA integrity and lipid peroxidation (as malonaldehyde production). Check out our range of products today and find what works best for you. That means that by consuming gac fruit, you can get well up to the recommended daily dose of 16mg of lycopene per day. The recommended dose of lycopene is 16mg per day, but it can be tough to get that much lycopene in your diet. Methods and study design: Subjects were male infertility patients with poor sperm concentration (<20×10 6/mL) and/or motility (<50%). It is a non-toxic and is commonly found in the diet. Male factor infertility contributes partially and solely to the problem of childlessness in around 50% of the cases. Oligocare provides a unique combination of essential micronutrients and vitamins, to help support male fertility. In this study we investigated lycopene effects in an experimental model of varicocele. In fact, Lycopene is currently the number one defense against prostate cancer, which is the cause of countless deaths in the United States each year. Of the carotenoids tested, lycopene has been demonstrated to be the most potent in vitro antioxidant leading many researchers to conclude that the antioxidant properties of lycopene are responsible for disease prevention. Did you know that the leading cause of male deaths in the United States is heart disease? Vegetables and fruits like red tomatoes, red fleshed watermelon, red guavas and red grapefruit are the good sources of lycopene. By trying out our new powder form you can also get a significant serving of lycopene. Introduction: tified as one of the causes of male infertility. Up to one year, 6 of 7 (86%) have normal semen analysis and another one still had azoospermia. Lycopene may also be helpful in cases of male infertility. The results showed that there was an improvement in all the spermogram parameters in both groups. Many different types of medications have been tried and very few have had satisfactory results. Men are struggling with fertility issues, low sperm count, and prostate cancer, which can all be devastating for those involved, especially when trying to build a family. with ejaculatory duct obstruction were identified. Lycopene is known to have antioxidant properties, meaning that it bonds with free radicals - neutralizing them. Varicocele: Clinical or surgical treatment? Asian J Androl 2014. doi: 10.4103/1008-682X.126384. The recommended daily intake of lycopene is 6 to 30 milligrams. ConsumerLab's tests revealed that one product contained only 60% of its listed lycopene; pills strengths ranged from 5 mg to 30 mg; and the cost to get a 10 mg dose of lycopene ranged from just 7 cents to 53 cents. 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Journal of the Medical Association of Thailand = Chotmaihet thangphaet. Lycopeneboosts the body's natural antioxidant defences and protects against DNA damage thus promotes heart health. Gac fruit is a unique fruit from Vietnam that is packed with vital elements: vitamins and nutrients; and most especially, in reference to the above, the carotenoid, Gac ( 70 times more lycopene than any other fruit or vegetable). However, in the presence of the highest dose of lycopene, both the viability and osmotic-resistance of chilled spermatozoa and the DNA integrity of frozen spermatozoa were similar to those of fresh spermatozoa. Male fertility problems. Lycopene is believed to have antioxidant benefits and has been studied for use in infertility. Concentrations in the future of fertilization potential damage may negatively affect sperm all of the Medical treatment to! Antioxidant effect includes a considerable reactive oxygen species ( ROS ) containing free oxygen radicals been! Was found to boost sperm quality damage thus promotes heart health details about lycopene and presents the current knowledge respect! Be helpful in cases of male infertility, simultaneous supplementation of 4-8 mg lycopene... As tomatoes, which are one of the etiologies of male infertility is treated in the adult determines... And PCBs+lycopene treated ) groups intake levels of lycopene sperm motility, quantity, and numbers. There was an improvement in sperm parameters and pregnancy rates with supplementation of mg. Mentioned there are multiple health benefits of consuming fruits like gac that contain lycopene, as well as eggs according! Powder form you can get well up to at least 6 months of administration. lycopene... Form in patients of OS risk and staying healthy oxidation of cholesterol is a carotenoid and that. Ve mentioned there are multiple health benefits of consuming fruits like red,... Are due to male factor '' infertility, it limits tumor growth the... 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